• Mitochondria are sensitive to both E-cig aerosols and metal nanoparticles.

• Increased mtROS by E-cig aerosol is associated with disrupted mitochondrial energy.

• E-cig causes nuclear DNA fragmentation.

• E-cig aerosols induce pro-inflammatory response in human fibroblasts.

• Users of electronic cigarette are increasing.

• The use of flavor in electronic cigarette affect cell viability and cell ultrastructure.

• Even the only vaping can stimulate proinflammatory cytokines release in cells.

• Electronic cigarette might not be harmless and affect cell physiology.

• Kupffer cells are responsive to classical cardiovascular risk factors.

• Kupffer cells can support complement activation and express gC1qR and cC1qR.

• After exposure to cigarettes, Kupffer cell activate innate immune responses.

• Liver innate immune responses may activate other cardiovascular cells.

 Conclusions

Our study showed that both cigarettes have unfavorable effects on markers of oxidative stress and FMD after single use, although e-Cigarettes seemed to have a lesser impact. Future studies are warranted to clarify the chronic vascular effects of e-Cigarette smoking.

 • Evaluated toxicity of e-liquid and its aerosols generated by e-cigarette using stress-responsive bacteria.

• Liquid e-juice inhibited growth by repressing genes responsible for cellular stress and repair.

• Solubilized e-juice aerosols do not inhibit growth but induce cellular stress and repair genes.

• Direct exposure of e-liquid in high doses could cause total cellular DNA fragmentation.

 ► The study compared the effect of light and regular cigarettes on endothelial function. ► The effect of chronic smoking on endothelial function is independent of the type of cigarette smoked. ► Even the lowest dose of cigarettes has a maximal detrimental effect on FMD. ► A single cigarette, both regular or light alike, impairs FMD even in chronic smokers. ► The so-called “light” cigarettes impair endothelial function as much as regular cigarettes. 

 Data are limited on the associated health hazards of e-cigarette use, particularly long-term effects, and available information often presents conflicting conclusions. In addition, an e-cigarette explosion and fire can pose a unique treatment challenge to the dental care provider because the oral cavity may be affected heavily. In this particular case, the patient’s injuries included intraoral burns, luxation injuries, and alveolar fractures. 

GRAPHENE OXIDE IN CIGARETTES' FILTERS

Patent: “Lyophilized carbon nanotubes/graphene oxide modified cigarette filter…” – https://www.sciencedirect.com/science/article/abs/pii/S1385894715007937 

Patent: “A graphene based tobacco smoke filter…” – https://patents.google.com/patent/WO2017187453A1/en